Thiazide Treatment Of Nephrogenic Diabetes Insipidus
In 1905 meyer in was the first to observe that diuretics decrease urinary volume in diabetes insipidus but it was only in 1959 that crawford and kennedy used thiazides to.
Thiazide treatment of nephrogenic diabetes insipidus. Libber s harrison h spector d. Acetazolamide might be an option to treat lithium induced nephrogenic diabetes insipidus patients who fail to respond to standard treatment. It might seem. Some treatments can reduce the symptoms of nephrogenic diabetes insipidus at least somewhat.
Nonsteroidal anti inflammatory drugs nsaids like ibuprofen motrin indomethacin indocin and naproxen. Desmopressin diabetes insipidus lithium indomethacin polyuria thiazide diuretics lithium carbonate is a well documented cause of nephrogenic diabetes insipidus with as many as 10 to 15 of patients taking lithium developing this condition. Waldhauser department of pediatrics university of vienna währinger gürtel 18 20 a 1090 vienna austria. Clinicians have been well aware of lithium toxicity for many years.
Treatment of nephrogenic diabetes insipidus with prostaglandin synthesis inhibitors. Vasopressin amiloride and thiazide diuretics have been used in lithium induced nephrogenic diabetes insipidus treatment. A low salt low protein diet reduces urine output. Treatment of nephrogenic diabetes insipidus with hydrochlorothiazide and amiloride v.
Seidl and f. Response to indomethacin and hydrochlorothiazide in nephrogenic diabetes insipidus. However the treatment of this drug. In rates with lithium induced nephrogenic di hctz reversed lithium induced downregulation of aqp2.
While these results are specific to li induced renal effects they may at least partially explain how a thiazide can serve to decrease polyuria in patients with diabetes insipidus. If you have more severe nephrogenic diabetes insipidus you may be prescribed a combination of thiazide diuretics and a non steroidal anti inflammatory drug nsaid to help reduce the amount of urine your kidneys produce. Monnens l jonkman a thomas c. Clin sci lond 1984.